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0 likes pentobarbital will lessen the level or effect of dienogest/estradiol valerate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Gals must not pick out estradiol valerate/dienogest as their contraceptive though using strong CYP3A4 inducers because of possible decrease in contraceptive efficacy.WARNING/Warning: Despit